Lunginnov - Products and Applications
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Lunginnov range of innovative Endocan/Endothelial cell Specific Molecule-1 (ESM-1) Products
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Endocan or ESM-1 (Endothelial cell Specific Molecule 1) is structurally a dermatan sulfate proteoglycan of 50 kDa which freely circulates in blood.

Endocan binds CD11a/CD18 integrin (also called LFA-1: Leukocyte Function-associated Antigen-1) on human leukocytes inhibiting its binding to ICAM-1. The expression of endocan/ESM-1 is upregulated by pro-inflammatory molecules such as tumor necrosis factor alpha (TNFa), lipopolysaccharides (LPS) and also pro-angiogenic molecules such as vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF-2). Endocan/ESM-1 binds via its dermatan sulfate chain to hepatocyte growth factor/scatter factor (HGF/SF).

Endocan/ESM-1 has been identified as a biomarker of tip cells.  Elevated blood levels of endocan/ESM-1 have been reported in patients with lung and kidney cancers as well as in patients with severe sepsis. Endocan appears to be a pertinent biomarker of endothelial dysfunction.
 
Lunginnov products include:
  Endocan Specific Monoclonal Antibodies
  Endocan Immunoassays (ELISA kits)
  Recombinant Endocan proteins
HOW TO FIND LUNGINNOV PRODUCTS:
By clicking on the next to "Price List" under the "Product/Applications Areas and Prices" links below, you will be taken to "Online Ordering" and a list of all Lunginnov products will be generated within the selected "Product/Application Area". From there the search can be further refined by selecting a "Product Group" and clicking on "Guided Search".

Alternatively, go directly to Online Ordering for a list of all Lunginnov products which can then be similarly searched by "Application Area" and then by "Product Group".

The SITE SEARCH function, at left, can also be used to find products. Enter the  product code or a full or a partial description of a product and click on "Seach". A list of ALL products within the Online Ordering database containing the item code or word(s) and/or keyword entered will be generated.
Examples of IHC detection using Lunginnov endocan/ESM-1 specific MEP08 monoclonal antibodies (Item Code: LIK-0901):
Brain Tumor
Immunostaining of glioma tumor cells and endothelial cells using the anti-endocan MEP08 antibodies (Courtesy of Pr. C.A. Maurage)
   
Kidney Cancer
Immunohistochemistry with MEP08 antibodies revealed the presence of endocan in intratumoral vasculature in clear cell renal cell carcinoma (Courtesy of Pr. X. Leroy)
   
Lung Cancer
Each intratumor vessel expressed endocan as revealed by immunohistochemistry using the MEP08 antibodies (Courtesy of Pr. M.C Copin)
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Pricing and Availability: A$ Prices are on this website, alternatively, please contact us for prices and availability on any of the Luninnov's range of products.
Go to Lunginnov Products/Application Areas Product/Application Areas and Prices:
Go to Monoclonal Antibody Products Monoclonal Antibodies
Go to Immunoassay Products Immunoassays (ELISA kits)
Go to Recombinant Protein Products Recombinant Proteins
Go to Other Products Ancillary Products
Literature References for Endocan/ESM-1
Reference List Title Size File
Cancer Research 858KB Download List of References
CVD and Obesity 356KB Download List of References
Sepsis 574KB Download List of References
Literature and Technical Requests
Product Information Sheets
Endocan ELISA Kits Endocan Recombinant Proteins
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Endocan Antibodies Products for non-Human Species
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Endocan/ESM-1 ELISA Kit Product Data Sheets
Product Code: LIK-1101 Product Code: LIK-1201
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Product Code: LIK-1205  
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Endocan/ESM-1 Product Application Sheets
Severe Sepsis (ELISA) Glioblastoma (IHC)
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Vascular Remodeling (IHC) Lung Cancer (IHC)
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 Pituitary Tumors (IHC) Renal Carcinoma (IHC)
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Technical Literature Request Request Technical Literature
For detailed information go to the Lunginnovwebsite:
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Product/Application Areas and Prices Product Groups
Monoclonal Antibodies
 
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Monoclonal Antibody Products:
  Anti-human mAbs to Endocan C-terminus epitope
  Anti-human biotinylated mAbs to Endocan C-terminus epitope
  Anti-human mAbs to Endocan N-terminus epitope
  Anti-human biotinylated mAbs to Endocan N-terminus epitope
  Anti-mouse mAbs to Endocan N-terminus epitope
  Anti-mouse biotinylated mAbs to Endocan N-terminus epitope
  Anti-mouse mAbs to Endocan internal epitope
  Anti-mouse biotinylated mAbs to Endocan internal epitope
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Immunoassays (ELISA kits)
 
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Immunoassays (ELISA kits) Products:
  ELISA kits to measure human Endocan
  ELISA kits to measure mouse Endocan
  ELISA kits to measure rat Endocan
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Recombinant Proteins
 
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Recombinant Protein Products:
  Recombinant human Endocan
  Recombinant mouse Endocan
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Ancillary Products
 
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Ancillary Products:
  Human Endocan Standard for ELISA kits
  Dermatan sulfate chains from recombinant human Endocan
  Other Products.
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