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Exalpha Biologicals - Products and Applications
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Exalpha Biologicals range of high quality  Products for Life Science Research
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Exalpha Biologicals was founded over 18 years ago by a group of scientists dedicated to accelerating the pace of discovery in the life sciences by developing and marketing unique products at the forefront of science. Exalpha biologicals continually monitors scientific trends and recent scientific literature and strives to produce products that answer real needs.  Exalpha biologicals has a long history of developing uniquely and superior products that simply perform well, allowing researchers to focus on the task at hand and not on the quality of a supplier’s products.
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Product/Application Areas Product Groups
Cell Proliferation and Apoptosis
Cell Cycle Proliferation Assays and Antibodies
Evaluation of cell cycle progression is essential for investigations in many scientific fields. Measurement of [3H] thymidine incorporation as cells enter S phase has long been the traditional method for the detection of cell proliferation. Subsequent quantification of [3H] thymidine is performed by scintillation counting or autoradiography. This technology is slow, labor intensive and has several limitations including the handling and disposal of radioisotopes and the necessity of expensive equipment.
 
A well-established alternative to [3H] thymidine uptake has been demonstrated by numerous investigators. In these methods bromodeoxyuridine (BrdU), a thymidine analog replaces [3H] thymidine. BrdU is incorporated into newly synthesized DNA strands of actively proliferating cells. Following partial denaturation of double stranded DNA, BrdU is detected immunochemically allowing the assessment of the population of cells, which are actively synthesizing DNA.
 
Cell Proliferation Products:
  Frontier™ Bromodeoxuridine (BrdU) Cell Proliferation ELISA
  Frontier™ Chemiluminescent Bromodeoxuridine (BrdU) Cell Proliferation ELISA
  Frontier™ Immunohistochemistry (BrdU) Cell Proliferation Kit
  Bromodeoxuridine (BrdU) Antibodies
 
Apoptosis DNA Fragmentation
Apoptosis, also known as programmed cell death or ankoikis, leads to the elimination of cells without releasing harmful substances into the surrounding area. Apoptosis is the result of a cascade of molecular and biochemical events involving endogenous endonucleases that cleave DNA into the prototypical ‘ladder of DNA fragments’. In addition to producing classical DNA ladders, the apoptotic endonucleases generate free 3’-OH groups at the ends of these DNA fragments to allow for the detection of apoptotic cells using a molecular biology-based, end-labeling technique.
 
Exalpha's Frontier™ ApoMark™ DNA Fragmentation Detection Kit is a non-isotopic system for the labelling of DNA breaks in apoptotic cell nuclei in paraffin-embedded tissue sections, tissue cryosections and in cell preparations fixed on slides.
 
Apoptosis DNA Fragmentation Product:
  Frontier™ ApoMark DNA Fragmentation Detection Kit
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CD Antibodies
CD Antibody Products:
  Single Colour Reagents and Negative Controls
  Bi-Test™ Reagents (FITC/RPE) and Negative Controls
  Three Colour Reagents (FITC/RPE/Cy5RPE)
  Second Step Reagents
  Flow Cytometry Kits
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Enzymes, Proteins and Other Products
Enzymes and Protein Products:
  Synthetic Proteins
  Recombinant Proteins
  Active Enzymes
  Purified Proteins
  Control Lysates
Other Products:
  Clinical IHC Markers
  GPCR's
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