4BioDx - Products and Applications
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4BioDx products for research into male infertility and nerodegenerative disease
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Male Infertility:
4BioDx range of ELISA kits, monoclonal and polyclonal antibodies are used in the investigation of male infertility, specifically targeting proAKAP4 (A-kinase anchor protein 4), an important biomarker of sperm motility.
 
Alzheimer's Disease:
In addition, 4BioDx has a range of monoclonal and polyclonal antibodies specific for several tau proteins and APP (amyloid protein precursors), which are important biomarkers for the investigation of the underlying processes of neurodegenerative diseases.
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Pricing and Availability: Please contact us for pricing and availability on any of the 4BioDx's range of products.
Literature and Technical Requests
Technical Literature Request Request Technical Literature
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The Importance of AKAP4 in male infertility
AKAP4 (A-kinase anchor protein 4) plays a central role in flagellar structure, chemotaxis, capacitation and in sperm motility. In mammals, AKAP4 is expressed during spermatogenesis. This 854 amino-acid protein is processed from a pro-AKAP4 (854 aa) to a “mature” AKAP4 protein lacking the first 188 amino acids. AKAP4 is specifically localised to the fibrous sheath of the principal piece of the flagellum a structure involved in flagellum structure and sperm motility.
 
AKAP4 (also named AKAP82) is a one of the major components (~50%) of the sperm fibrous sheath. The AKAP4 precursor termed proAKAP4 is processed to mature AKAP4 during sperm maturation in the testes. In humans, the AKAP4 gene is located on the X chromosome.
 
In the literature, AKAP4 was previously named AKAP82, PRKA4 (Protein Kinase A Anchoring Protein 4), CT99 (Cancer/Testis Antigen 99), HI, p82, or FSC1 (Fibrous Sheath Component 1). AKAP4 protein belongs to the family of A-kinase anchor proteins (AKAPs) all sharing a common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the PKA holoenzyme to discrete locations within the cell. Therefore, AKAP4 is an essential regulator of PKA and PKC protein kinases signalling to the motor protein dynein of the axoneme of the flagellum.
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